Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.51 |
| ▸ | JAK3 | P52333 | 9/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | TYK2 | P29597 | 5/20 | 0.46 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561800 | 0.91 | JAK2 (0.43) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL5021905 | 0.88 | JAK2 (0.57) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL27935913 | 0.88 | JAK2 (0.49) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4562331 | 0.88 | JAK2 (0.49) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL27935907 | 0.86 | JAK2 (0.52) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4559900 | 0.84 | JAK3 (0.45) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4561206 | 0.83 | JAK2 (0.45) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4561248 | 0.83 | JAK3 (0.44) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL5021903 | 0.83 | ALDH1A1 (0.45) | JAK2JAK3HDAC1HDAC6JAK1 | |
| SCHEMBL4562646 | 0.83 | JAK2 (0.48) | JAK2JAK3JAK1TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |