Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 8/20 | 0.35 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | PPARD | Q03181 | 6/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27950251 | 0.86 | RORC (0.41) | CYP3A4CYP2C19CYP2C9MAPK1PPARG | |
| SCHEMBL12096834 | 0.81 | PPARG (0.46) | CYP3A4CYP2C19CYP2C9MAPK1PPARG | |
| SCHEMBL27950350 | 0.81 | PPARG (0.35) | CYP3A4CYP2C19CYP2C9MAPK1PPARG | |
| SCHEMBL27936033 | 0.79 | RORC (0.41) | CYP3A4CYP2C19CYP2C9MAPK1PPARG | |
| SCHEMBL12096867 | 0.77 | PPARG (0.47) | PPARGPPARAPPARDPHGDHCA12 | |
| SCHEMBL28775092 | 0.75 | AKR1C3 (0.39) | PPARGPPARAPPARDPHGDH | |
| SCHEMBL28809335 | 0.75 | POLB (0.34) | CYP3A4CYP2C19CYP2C9MAPK1PPARG | |
| SCHEMBL28947564 | 0.74 | RORC (0.39) | PPARGPPARAPPARDCA1CA2 | |
| SCHEMBL27833814 | 0.73 | PPARG (0.37) | CYP3A4CYP2C9PPARGPPARAPPARD | |
| SCHEMBL27813772 | 0.73 | PPARG (0.36) | CYP3A4CYP2C9PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |