Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209559 | 0.81 | RAB9A (0.39) | KMT2ARAB9ANPC1MEN1TP53 | |
| SCHEMBL210936 | 0.81 | ALDH1A1 (0.41) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL211381 | 0.79 | KMT2A (0.48) | KMT2ARAB9ANPC1MEN1POLB | |
| SCHEMBL209913 | 0.79 | GCK (0.39) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL212593 | 0.79 | EPHX2 (0.39) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL212616 | 0.78 | RAB9A (0.60) | KMT2ARAB9ANPC1MEN1TP53 | |
| SCHEMBL212071 | 0.78 | ALDH1A1 (0.56) | RAB9ANPC1TP53SMN1; SMN2LMNA | |
| SCHEMBL4342546 | 0.78 | RAB9A (0.58) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL8509643 | 0.78 | KMT2A (0.48) | KMT2ARAB9ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL211547 | 0.77 | CSNK1D (0.46) | RAB9ANPC1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |