Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28809104 | 0.85 | LRRK2 (0.46) | KDM4AKDM5AKDM4CKDM5BLRRK2 | |
| SCHEMBL13734939 | 0.84 | PTGS2 (0.45) | LRRK2SMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL13733749 | 0.81 | PTGS2 (0.52) | SMN1; SMN2KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL13735481 | 0.79 | KDM5A (0.47) | KDM5AKDM4CKDM5BMAOAMAOB | |
| SCHEMBL27948417 | 0.77 | RPS6KA3 (0.47) | KDM5AKDM4CKDM5BSMN1; SMN2ALDH1A1 | |
| SCHEMBL13735240 | 0.77 | MAP4K1 (0.47) | SMN1; SMN2KDM4EMAPTNPC1ALDH1A1 | |
| SCHEMBL29183323 | 0.76 | STAT6 (0.41) | SMN1; SMN2KDM4EMAPTNPC1ALDH1A1 | |
| SCHEMBL28809102 | 0.73 | — | — | |
| SCHEMBL13737174 | 0.73 | KDM4A (0.46) | KDM4AKDM5AKDM4CKDM5BKDM4E | |
| SCHEMBL13733810 | 0.73 | MAPT (0.58) | LRRK2SMN1; SMN2KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | claimed |
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |