Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27933174 | 0.88 | HSP90AA1 (0.45) | LRRK2HSP90AA1MEN1KMT2AAR | |
| SCHEMBL28809098 | 0.85 | KDM4A (0.47) | LRRK2KDM4AKDM5AKDM4CKDM5B | |
| SCHEMBL28807011 | 0.83 | ALDH1A1 (0.48) | LRRK2KDM5AKDM4CKDM5BKMT2A | |
| SCHEMBL27948412 | 0.82 | KDM5A (0.46) | LRRK2KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL27948410 | 0.81 | HPGD (0.48) | HSP90AA1MEN1KMT2AP2RX7ALDH1A1 | |
| SCHEMBL27948419 | 0.80 | NR3C2 (0.43) | KDM5AKDM4CKDM5BHSP90AA1MEN1 | |
| SCHEMBL27933075 | 0.78 | CNR2 (0.51) | LRRK2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL27932732 | 0.77 | PTGS2 (0.50) | ARALDH1A1HSD17B10SMN1; SMN2NPSR1 | |
| SCHEMBL28903748 | 0.75 | MAP4K1 (0.49) | LRRK2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL27932740 | 0.75 | MAPK9 (0.47) | MEN1KMT2AARHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | claimed |
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |