Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555029 | 0.95 | — | — | |
| Bicarbonate SCHEMBL28747310 | 0.80 | CYP3A4 (0.38) | TSHRALDH1A1CYP3A4TDP1 | |
| SCHEMBL599364 | 0.78 | — | — | |
| Alcohol SCHEMBL8026692 | 0.76 | TSHR (0.36) | TSHRALDH1A1CYP3A4TDP1 | |
| SCHEMBL1243374 | 0.76 | ALDH1A1 (0.41) | TSHRALDH1A1CYP3A4TDP1 | |
| SCHEMBL8021110 | 0.75 | CYP3A4 (0.35) | TSHRALDH1A1CYP3A4TDP1 | |
| L-Fucose SCHEMBL1130505 | 0.75 | — | — | |
| SCHEMBL8376050 | 0.74 | — | — | |
| SCHEMBL7117503 | 0.73 | — | — | |
| SCHEMBL30083352 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716614-A | Preparation method of silane crosslinked polyethylene cable material grafting material | 中国石油天然气股份有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-114716614-A | Preparation method of silane crosslinked polyethylene cable material grafting material | 中国石油天然气股份有限公司 | 2022-07-08 | — | — | CN | disclosed |