Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27940224 | 0.99 | NTSR1 (0.46) | NTSR1DRD4DRD2KCNH2SIGMAR1 | |
| SCHEMBL28809553 | 0.82 | DRD4 (0.40) | NTSR1DRD4DRD2KCNH2SIGMAR1 | |
| SCHEMBL27940225 | 0.81 | DRD4 (0.41) | NTSR1DRD4DRD2KCNH2SIGMAR1 | |
| SCHEMBL13739264 | 0.75 | USP14 (0.50) | DRD4DRD2HTR2CMAPK1RECQL | |
| SCHEMBL27940195 | 0.74 | DRD4 (0.41) | DRD4DRD2HTR2CMAPK1RECQL | |
| SCHEMBL13739719 | 0.74 | NPC1 (0.51) | DRD4DRD2HTR2CMAPK1RECQL | |
| SCHEMBL681153 | 0.73 | NTSR1 (0.59) | NTSR1SIGMAR1USP2ALOX15TSHR | |
| SCHEMBL12194487 | 0.73 | NTSR1 (0.59) | NTSR1SIGMAR1USP2ALOX15TSHR | |
| SCHEMBL681312 | 0.73 | NTSR1 (0.59) | NTSR1SIGMAR1USP2ALOX15TSHR | |
| SCHEMBL679611 | 0.71 | NTSR1 (0.56) | NTSR1USP2ALOX15TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103635230-A | Proteostasis regulators | PROTEOSTASIS THERAPEUTICS INC | 2014-03-12 | — | — | CN | disclosed |