SCHEMBL2880995

SCHEMBL2880995

O=CN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MME P08473 12/20 0.58
ACE2 Q9BYF1 6/20 0.52
ACE P12821 5/20 0.52
CPA1 P15085 5/20 0.52
NAALAD2 Q9Y3Q0 1/20 0.51
MMP2 P08253 1/20 0.49
MMP7 P09237 1/20 0.49
MMP9 P14780 1/20 0.49
MMP12 P39900 1/20 0.49
MMP13 P45452 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7165248 1.00 MME (0.58) MMEACE2ACECPA1NAALAD2
SCHEMBL9657150 1.00 MME (0.58) MMEACE2ACECPA1NAALAD2
SCHEMBL7032940 1.00 MME (0.58) MMEACE2ACECPA1NAALAD2
SCHEMBL15739447 0.91 MME (0.62) MMEACE2ACECPA1
SCHEMBL10359803 0.89 MME (0.55) MMEACE2ACECPA1MMP2
SCHEMBL19932059 0.89 FCER2 (0.51) MMEACE
SCHEMBL7030032 0.87 ALDH1A1 (0.60)
SCHEMBL10907014 0.87 ALDH1A1 (0.60)
SCHEMBL6545851 0.87 ALDH1A1 (0.60)
SCHEMBL9169974 0.87 ALDH1A1 (0.60)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104628819-A Technique for generating aspartame by coupling reaction CHANGMAO BIOCHEMICAL ENGINEERING CO LTD 2015-05-20 CN claimed
CN-102206246-A Aqueous synthesis method for N-formyl-alpha-L-aspartoyl-L-phenylalanine JIANG WU 2011-10-05 CN claimed
US-6617127-B2 Using N-formylaspartylphenylalanine compound HOLLAND SWEETENER COMPANY, V.O.F. (NL) 2003-09-09 US claimed
EP-1140982-B1 SYNTHESIS AND RECOVERY OF ASPARTAME INVOLVING ENZYMATIC DEFORMYLATION STEP HOLLAND SWEETENER CO (NL) 2003-04-23 EP claimed
EP-0986575-B1 METHOD FOR PREPARING SALTS OF ASPARTAME FROM N-PROTECTED ASPARTAME HOLLAND SWEETENER CO (NL) 2003-04-23 EP claimed
US-20020025549-A1 Synthesis and recovery of aspartame involving enzymatic deformylation step DSM IP ASSETS BV (NL) 2002-02-28 US claimed
EP-1013663-A1 Synthesis and recovery of aspartame involving enzymatic deformylation step Holland Sweetener Company V.O.F. (NL) 2000-06-28 EP claimed
EP-0704440-B1 A method of preparing N-formyl-L-aspartic anhydride AJINOMOTO KK (JP) 1998-09-09 EP claimed
EP-0526854-B1 Method for recovery of alpha-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and l-aspartic acid AJINOMOTO KK (JP) 1997-05-02 EP claimed
US-5623079-A REACTING ASPARTIC ACID WITH ACETIC ANHYDRIDE AND FORMIC ACID TO FORM N-FORMYL-L-ASPARTIC ANHYDRIDE, CENTRIFUGING TO FORM A CAKE, BACK-PRESSURIZING, DEPRESSURIZING, FILTERING OR DEHYDRATING AJINOMOTO CO., INC. (JP) 1997-04-22 US claimed
US-4745210-A AMIDATION OF PHENYLALANINE WITH ANHYDRIDE MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1988-05-17 US claimed
EP-0200311-A2 Preparation process of alpha-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-11-05 EP claimed
EP-0196866-A2 Preparation process of alpha-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-10-08 EP claimed
EP-0187530-A2 Process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-07-16 EP claimed
EP-0186378-A2 Process for the preparation of N-formyl-alpha-aspartyl phenylalanine MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-07-02 EP claimed
EP-0058063-B1 PROCESS FOR REMOVING AN N-FORMYL GROUP AJINOMOTO CO., INC. (JP) 1984-05-23 EP claimed
US-4434097-A Process for the removal of the formyl group from N-formyl peptides and esters thereof PIERREL S.P.A. (IT) 1984-02-28 US claimed
EP-0058063-A1 Process for removing an n-formyl group AJINOMOTO CO., INC. (JP) 1982-08-18 EP claimed
US-4173562-A ESTERIFICATION, SALT FORMATION MONSANTO COMPANY (US) 1979-11-06 US claimed
US-3933781-A Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters MONSANTO COMPANY (US) 1976-01-20 US claimed