Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | CLK3 | P49761 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27969894 | 0.83 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL4805509 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL1853725 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL28383003 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL31691908 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL27851181 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL20004291 | 0.75 | DAO (0.53) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL19362482 | 0.75 | DAO (0.49) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL5314190 | 0.72 | MAPT (0.51) | DAOPDE3BPDE3AMAPTSNCA | |
| SCHEMBL24492928 | 0.71 | DAO (0.49) | DAOPDE3BPDE3AMAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196804-B | TGF-beta R1 inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-105683175-B | Two ring inhibitor | 卡尔维斯塔制药有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-104955824-B | It is used as the aminopyrimidine compounds of the inhibitor of the EGFR mutant containing T790M | 豪夫迈·罗氏有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-105683175-A | BICYCLIC INHIBITORS | 卡尔维斯塔制药有限公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-104955824-A | Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants | GENENTECH INC | 2015-09-30 | — | — | CN | disclosed |
| CN-102046240-B | Novel P2X7R antagonists and their use | AFFECTIS PHARMACEUTICALS AG | 2014-06-25 | — | — | CN | disclosed |
| CN-103492376-A | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LTD | 2014-01-01 | — | — | CN | disclosed |