Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493634 | 0.86 | — | — | |
| SCHEMBL15328337 | 0.79 | MEN1 (0.36) | PRMT1CA1CA2ADRA1AEPHX2 | |
| SCHEMBL5120839 | 0.79 | MEN1 (0.41) | PRMT1CA1CA2ADRA1AKDM4E | |
| SCHEMBL5128168 | 0.77 | KDM4E (0.41) | PRMT1CA1CA2ADRA1AEPHX2 | |
| SCHEMBL13731191 | 0.76 | PRMT1 (0.48) | PRMT1CA1CA2ADRA1AKDM4E | |
| SCHEMBL320940 | 0.75 | PRMT1 (0.58) | PRMT1ADRA1AATMPLA2G4AEPHX2 | |
| SCHEMBL11213979 | 0.75 | CASP2 (0.60) | MEN1KMT2A | |
| SCHEMBL28945607 | 0.74 | PRMT1 (0.52) | PRMT1ADRA1AKDM4EMAPK1HIF1A | |
| SCHEMBL27130042 | 0.74 | PRMT1 (0.52) | PRMT1ADRA1AKDM4EMAPK1HIF1A | |
| SCHEMBL8958360 | 0.74 | KDM4E (0.43) | PRMT1CA1CA2ADRA1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114746419-A | N- (3- (5- (pyrimidin-4-yl) thiazol-4-yl) phenyl) sulfonamide compounds and their use as BRAF inhibitors | 国家医疗保健研究所 | 2022-07-12 | — | — | CN | disclosed |