Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KRAS | P01116 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28810211 | 0.85 | KRAS (0.51) | NPC1RAB9AKRASPOLBUSP30 | |
| SCHEMBL18546446 | 0.81 | HTR6 (0.44) | KRASKMT2AUSP30LMNASMN1; SMN2 | |
| SCHEMBL23534379 | 0.80 | NPC1 (0.48) | NPC1RAB9AKRASALDH1A1POLB | |
| SCHEMBL23533928 | 0.78 | USP30 (0.54) | KRASALDH1A1POLBKMT2AUSP30 | |
| SCHEMBL1846302 | 0.78 | HTR6 (0.46) | NPC1KRASKMT2AUSP30LMNA | |
| SCHEMBL29754156 | 0.78 | HTR6 (0.46) | NPC1KRASKMT2AUSP30LMNA | |
| SCHEMBL18555717 | 0.77 | HTR6 (0.45) | KRASUSP30LMNASMN1; SMN2HTR6 | |
| SCHEMBL15059343 | 0.77 | KRAS (0.48) | KRASKMT2AUSP30LMNASMN1; SMN2 | |
| SCHEMBL28810229 | 0.77 | USP30 (0.61) | KRASUSP30 | |
| SCHEMBL8091551 | 0.75 | KMT2A (0.51) | KRASALDH1A1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114867718-A | Novel indazole derivative and use thereof | 韩国化学研究院 | 2022-08-05 | — | — | CN | disclosed |