Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881337 | 0.87 | GPR119 (0.56) | GPR119 | |
| SCHEMBL3841477 | 0.84 | GPR119 (0.54) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL387199 | 0.84 | GPR119 (0.59) | GPR119 | |
| SCHEMBL3841482 | 0.83 | GPR119 (0.51) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL3844800 | 0.81 | HRH3 (0.44) | GPR119HRH3GRIN2B | |
| SCHEMBL3840018 | 0.80 | GRIN2B (0.50) | GPR119HRH3GRIN2B | |
| SCHEMBL3839998 | 0.79 | GPR119 (0.51) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL2880903 | 0.78 | GPR119 (0.49) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL2881232 | 0.76 | GPR119 (0.61) | GPR119CYP4F2CYP4A11 | |
| SCHEMBL2876156 | 0.76 | GPR119 (0.58) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010512334-A | — | — | 2010-04-22 | — | — | JP | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |