Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865849 | 0.87 | GPR119 (0.52) | GPR119 | |
| SCHEMBL3840018 | 0.85 | GRIN2B (0.50) | HRH3GRIN2BGPR119ACACBTLR9 | |
| SCHEMBL3841477 | 0.84 | GPR119 (0.54) | GPR119 | |
| SCHEMBL387056 | 0.82 | GPR119 (0.49) | GPR119 | |
| SCHEMBL24493183 | 0.82 | GRIN2B (0.55) | GRIN2B | |
| SCHEMBL30578289 | 0.82 | GRIN2B (0.55) | GRIN2B | |
| SCHEMBL3988752 | 0.81 | LIPE (0.44) | HRH3LIPEGPR119ACACB | |
| SCHEMBL2881159 | 0.81 | GPR119 (0.47) | HRH3GRIN2BGPR119 | |
| SCHEMBL2883378 | 0.81 | GPR119 (0.56) | GPR119 | |
| SCHEMBL3841482 | 0.80 | GPR119 (0.51) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |