Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28107383 | 0.88 | CA1 (0.51) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL30517409 | 0.78 | CA1 (0.60) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL14675926 | 0.78 | CA1 (0.60) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL28592429 | 0.76 | F2 (0.56) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL28811181 | 0.72 | MEN1 (0.42) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL28210786 | 0.72 | KMT2A (0.51) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL1317710 | 0.72 | KMT2A (0.63) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL29508624 | 0.72 | KMT2A (0.63) | THRBCA1CA2MMP1MMP2 | |
| SCHEMBL28446977 | 0.72 | ALDH1A1 (0.63) | KMT2AMEN1TDP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL999377 | 0.71 | KMT2A (0.68) | THRBCA1CA2MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103857655-B | Compounds for inhibiting 11 beta-hydroxysteroid dehydrogenase 1 and pharmaceutical compositions comprising the same | HYUNDAI PHARM Co.,Ltd. (KR) | 2016-03-30 | — | — | CN | disclosed |
| CN-103857655-A | Compounds for inhibiting 11 beta-hydroxysteroid dehydrogenase 1 and pharmaceutical compositions comprising the same | HYUNDAI PHARM CO LTD | 2014-06-11 | — | — | CN | disclosed |