Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 5/20 | 0.48 |
| ▸ | CTSK | P43235 | 5/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | CTSH | P09668 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094 | 0.86 | ATM (0.62) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL390555 | 0.86 | ATM (0.62) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL1094506 | 0.86 | ATM (0.62) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL8539393 | 0.85 | KLK5 (0.52) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL7348278 | 0.82 | CTSB (0.57) | CTSBCTSSCTSLACECA12 | |
| SCHEMBL2721558 | 0.81 | ACE (0.60) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL1691095 | 0.81 | ACE (0.60) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL2736190 | 0.80 | ATM (0.61) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL12137049 | 0.80 | ATM (0.61) | ATMCTSBCTSKCTSSCTSL | |
| SCHEMBL21791093 | 0.80 | ATM (0.52) | ATMCTSBCTSKCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103826661-A | Novel binding agent-drug conjugates (ADCs) and uses thereof | SEATTLE GENETICS INC | 2014-05-28 | — | — | CN | disclosed |
| CN-103764170-A | Novel binder-drug conjugates (ADCs) and their use | SEATTLE GENETICS INC | 2014-04-30 | — | — | CN | disclosed |