SCHEMBL390555

SCHEMBL390555

CC(C)(C)OC(=O)NC(C=O)Cc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.62
CTSK P43235 10/20 0.57
CTSB P07858 5/20 0.56
CTSL P07711 4/20 0.56
CTSS P25774 2/20 0.56
ACE P12821 1/20 0.54
CTSH P09668 1/20 0.53
CAPN1 P07384 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1094506 1.00 ATM (0.62) ATMCTSKCTSBCTSLCTSS
SCHEMBL7094 1.00 ATM (0.62) ATMCTSKCTSBCTSLCTSS
SCHEMBL9929938 0.92 CTSK (0.61) ATMCTSKCTSBCTSLCTSS
SCHEMBL19924528 0.92 ATM (0.54) ATMCTSKCTSBCTSLCTSS
SCHEMBL598263 0.92 CTSK (0.61) ATMCTSKCTSBCTSLCTSS
SCHEMBL8523201 0.92 CTSK (0.61) ATMCTSKCTSBCTSLCTSS
SCHEMBL2736190 0.91 ATM (0.61) ATMCTSKCTSBCTSLCTSS
SCHEMBL12137049 0.91 ATM (0.61) ATMCTSKCTSBCTSLCTSS
SCHEMBL20204705 0.90 CTSS (0.65) ATMCTSKCTSBCTSLCTSS
SCHEMBL22962275 0.90 CTSS (0.65) ATMCTSKCTSBCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10272103-B2 Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants RELYPSA, INC. (US) 2019-04-30 US claimed
US-20170258825-A1 AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS RELYPSA, INC. 2017-09-14 US claimed
EP-2998329-A2 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS Relypsa, Inc. (US) 2016-03-23 EP claimed
US-20160051576-A1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS RELYPSA, INC. (US) 2016-02-25 US claimed
EP-1512397-B1 O-SUBSTITUTED HYDROXYARYL DERIVATIVES INST MED MOLECULAR DESIGN INC (JP) 2014-10-08 EP claimed
EP-2539380-A2 CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS Relypsa, Inc. (US) 2013-01-02 EP claimed
WO-2011106542-A2 CROSSLINKED POLYVRNYLAMINE, POLY ALL YLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS RELYPSA, INC. (US) 2011-09-01 WO claimed
US-20100113770-A1 O-SUBSTITUTED HYDROXYARYL DERIVATIVES INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2010-05-06 US claimed
US-RE36718-E 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL DERIVATIVES KANEKA CORPORATION (JP) 2000-05-30 US claimed
US-5616726-A AN 3-AMINO-1-NITRO-4-PHENYL-2-BUTANOL BY ADDING NITROMETHANE STEREOSELECTIVELY IN THE PRESENCE OF A BASE TO AN OPTICAL ACTIVE AMINOALDEHYDE; CHEMICAL INTERMEDIATES FOR DRUGS; E.G. THE ANTICARCINOGENIC AGENT, BESTATIN KANEKA CORPORATION (JP) 1997-04-01 US claimed
EP-0657415-A1 OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE AND PROCESS FOR PRODUCING THE SAME KANEKA CORPORATION (JP) 1995-06-14 EP claimed
US-12612414-B2 Nitrile SUMO inhibitors and uses thereof CIT THERAPEUTICS, INC. (US) 2026-04-28 US disclosed
US-12454502-B2 Synthesis of deuterated aldehydes ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIVERSITY OF ARIZONA (US) 2025-10-28 US disclosed
US-20250188040-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS VIVIDION THERAPEUTICS INC 2025-06-12 US disclosed
EP-4551555-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS Vividion Therapeutics, Inc. (US) 2025-05-14 EP disclosed
US-4826815-A HYPOTENSIVE ABBOTT LABORATORIES (US) 1989-05-02 US disclosed
EP-0260668-A2 Separation of diastereomers WARNER-LAMBERT COMPANY (US) 1988-03-23 EP disclosed
US-4681972-A Separation of diastereomers WARNER-LAMBERT COMPANY (US) 1987-07-21 US disclosed
US-4657931-A RENIN-INHIBITING G. D. SEARLE & CO. (US) 1987-04-14 US disclosed
EP-0202577-A2 N(Acyldipeptidyl)-aminoglycols G.D. Searle & Co. (US) 1986-11-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160051576-A1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS NR1H4, SLC10A2, GPBAR1 ATM 2057/4885CTSK 4156/4885CTSB 4421/4885
US-12454502-B2 Synthesis of deuterated aldehydes ADH1C, ADH1A, CBR1 ATM 1452/4885CTSK 2382/4885CTSB 3253/4885
US-20170258825-A1 AMINE POLYMERS FOR USE AS BILE ACID SEQUESTRANTS NR1H4, SLC10A2, SLC10A1 ATM 1814/4885CTSK 3267/4885CTSB 3144/4885
US-12612414-B2 Nitrile SUMO inhibitors and uses thereof SUMO1, SUMO3, PSMB6 ATM 3356/4885CTSK 2087/4885CTSB 1625/4885
US-10272103-B2 Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants NR1H4, SLC10A2, GPBAR1 ATM 2057/4885CTSK 4156/4885CTSB 4421/4885
US-20100113770-A1 O-SUBSTITUTED HYDROXYARYL DERIVATIVES RELA, NFKBIA, NFE2 ATM 1205/4885CTSK 1259/4885CTSB 1263/4885
US-20250188040-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS RECQL, BLM, WRN ATM 523/4885CTSK 3934/4885CTSB 3950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.