SCHEMBL28813740

SCHEMBL28813740

O=C[CH]Nc1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
TSHR P16473 1/20 0.42
TGM2 P21980 1/20 0.41
NPC1 O15118 5/20 0.40
RAB9A P51151 5/20 0.40
SMN1; SMN2 Q16637 5/20 0.40
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
STAT1 P42224 1/20 0.40
MAPT P10636 3/20 0.38
TP53 P04637 2/20 0.38
PKM P14618 1/20 0.38
HTT P42858 2/20 0.37
KDM4E B2RXH2 2/20 0.37
GAA P10253 2/20 0.37
APP P05067 1/20 0.37
SNCA P37840 1/20 0.37
BRCA1 P38398 1/20 0.37
CA12 O43570 1/20 0.36
MMP2 P08253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL90440 0.80 ALDH1A1 (0.56) ALDH1A1TSHRTGM2NPC1RAB9A
Hydrochloric Acid SCHEMBL27616318 0.78 ALDH1A1 (0.54) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL27978234 0.76 HSD17B10 (0.42) ALDH1A1TSHRNPC1RAB9ASMN1; SMN2
SCHEMBL28324222 0.75 ALDH1A1 (0.64) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL23513176 0.70 TGM2 (0.48) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL3483051 0.70 ALDH1A1 (0.40) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL13818699 0.70 ALDH1A1 (0.40) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL14368315 0.70 FFAR1 (0.46) ALDH1A1TSHRRAB9AMAPTGAA
SCHEMBL28063064 0.70 ALDH1A1 (0.41) ALDH1A1TSHRTGM2NPC1RAB9A
SCHEMBL14701703 0.69 ALDH1A1 (0.47) ALDH1A1TSHRTGM2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104161757-A Application of mercaptonicotinic acid compounds AMMS CHINA 2014-11-26 CN claimed
CN-104161757-A Application of mercaptonicotinic acid compounds AMMS CHINA 2014-11-26 CN disclosed