Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.35 |
| ▸ | ELOVL6 | Q9H5J4 | 6/20 | 0.35 |
| ▸ | CBX7 | O95931 | 1/20 | 0.35 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.35 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467575 | 0.83 | IDO1 (0.43) | IDO1AKR1B1MEN1KMT2APDK2 | |
| SCHEMBL2472430 | 0.79 | MEN1 (0.43) | IDO1AKR1B1MEN1KMT2APDK2 | |
| SCHEMBL2474367 | 0.78 | MDM2 (0.41) | IDO1MEN1KMT2APDK2ELOVL6 | |
| SCHEMBL2470044 | 0.77 | ELOVL6 (0.42) | IDO1MEN1KMT2AELOVL6 | |
| SCHEMBL2471187 | 0.76 | MDM2 (0.44) | IDO1AKR1B1MEN1KMT2A | |
| SCHEMBL2467447 | 0.75 | MAPT (0.36) | IDO1AKR1B1MEN1KMT2ACYP46A1 | |
| SCHEMBL2472161 | 0.75 | CYP46A1 (0.42) | IDO1AKR1B1CYP46A1ELOVL6CBX7 | |
| SCHEMBL2469490 | 0.75 | ELOVL6 (0.38) | IDO1AKR1B1CYP46A1ELOVL6 | |
| SCHEMBL2469599 | 0.74 | CYP46A1 (0.39) | IDO1AKR1B1MEN1KMT2ACYP46A1 | |
| SCHEMBL2472750 | 0.74 | CYP46A1 (0.43) | IDO1AKR1B1MEN1KMT2ACYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745452-B2 | Quinazolinone T-type calcium channel antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME LLC | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167329-A1 | Quinazolinone T-Type Calcium Channel Antagonists | CACNA1I, CACNA1G, CACNA1H | IDO1 1782/4885AKR1B1 2683/4885MEN1 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.