Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881473 | 1.00 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL2881474 | 1.00 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| Hydrochloric Acid SCHEMBL2887523 | 0.99 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| Hydrochloric Acid SCHEMBL2887518 | 0.99 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| Hydrochloric Acid SCHEMBL2887521 | 0.99 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CCHEK1 | |
| SCHEMBL2887001 | 0.92 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2887955 | 0.91 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2887949 | 0.91 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2887953 | 0.91 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5056368 | 0.91 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776893-B2 | Use of PDE4 inhibitors for the treatment of diabetes mellitus | NYCOMED GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20060281745-A1 | Use of pde4 inhibitors for the treatment of diabetes mellitus | ALTANA PHARMA AG (DE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281745-A1 | Use of pde4 inhibitors for the treatment of diabetes mellitus | PDE4A, PDE4B, PDE12 | PDE4D 4/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.