Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5057946 | 1.00 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL7400096 | 1.00 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL7205164 | 1.00 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL7960463 | 0.92 | PDE4D (0.47) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL2881473 | 0.91 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CATM | |
| SCHEMBL2881474 | 0.91 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CATM | |
| SCHEMBL2881470 | 0.91 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CATM | |
| SCHEMBL2887001 | 0.90 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| Hydrochloric Acid SCHEMBL2887518 | 0.90 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CATM | |
| Hydrochloric Acid SCHEMBL2887521 | 0.90 | PDE4D (0.51) | PDE4DPDE4BPDE4APDE4CATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | NYCOMED GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
| EP-1858880-A1 | AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES | Nycomed GmbH (DE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006095009-A1 | AMIDO-SUBSTITUTED 6-PHENYLPHENANTHRIDINES | NYCOMED GMBH (DE) | 2006-09-14 | — | — | WO | disclosed |
| US-20060116518-A1 | Novel phenanthridines | ALTANA PHARMA AG (DE) | 2006-06-01 | — | — | US | disclosed |
| EP-1537086-A2 | NOVEL PHENANTHRIDINES | ALTANA Pharma AG (DE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004018431-A2 | NOVEL PHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |
| EP-0882021-B1 | NEW PHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2003-03-05 | — | — | EP | disclosed |
| WO-2002006239-A1 | PHENANTHRIDINE N-OXIDES | ALTANA PHARMA AG (DE) | 2002-01-24 | — | — | WO | disclosed |
| US-6191138-B1 | THERAPY FOR RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | PDE4A, PDE4B, PDE3A | PDE4D 7/4885PDE4B 2/4885PDE4A 1/4885 |
| US-20060116518-A1 | Novel phenanthridines | PDE4A, PDE4B, PDE3A | PDE4D 6/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.