Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883495 | 0.89 | HRH3 (1.00) | HRH3PDE5A | |
| SCHEMBL13085754 | 0.86 | HRH3 (0.76) | HRH3ALDH1A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL2892498 | 0.83 | HRH3 (0.71) | HRH3PDE5A | |
| SCHEMBL1811328 | 0.82 | HRH3 (0.62) | HRH3ATR | |
| SCHEMBL2886484 | 0.82 | HRH3 (0.72) | HRH3CYP11B1CYP11B2ATR | |
| SCHEMBL2881480 | 0.81 | HRH3 (0.60) | HRH3ALDH1A1CYP11B1CYP11B2IDO1 | |
| SCHEMBL2887674 | 0.79 | HRH3 (0.78) | HRH3ATRPDE5A | |
| SCHEMBL2885714 | 0.79 | HRH3 (0.78) | HRH3CYP11B2ATRPDE5A | |
| SCHEMBL2879391 | 0.79 | HRH3 (0.76) | HRH3CYP11B2PDE5A | |
| SCHEMBL2884328 | 0.79 | HRH3 (0.76) | HRH3CYP11B2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820825-B2 | N-substituted-azacyclylamines as histamine-3 antagonists | WYETH LLC (US) | 2010-10-26 | — | — | US | disclosed |