Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14914993 | 0.72 | KMT2A (0.53) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 | |
| Ethoxycarbonyl Group SCHEMBL28815733 | 0.70 | PDE10A (0.43) | MAPTKDM4EALDH1A1BRD9SMN1; SMN2 | |
| SCHEMBL14916359 | 0.69 | PDE4A (0.46) | MAPTRECQLBRD9MAPK1PDE4A | |
| SCHEMBL14916146 | 0.65 | PDE10A (0.60) | MAPTKDM4EALDH1A1POLBPDE10A | |
| SCHEMBL324627 | 0.64 | ALDH1A1 (0.35) | MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL18832978 | 0.64 | PDE10A (0.55) | MAPTKDM4EALDH1A1CYP2C19PDE10A | |
| SCHEMBL31427207 | 0.63 | RECQL (0.43) | MAPTRECQLKDM4EALDH1A1 | |
| SCHEMBL27473534 | 0.63 | HTR2A (0.55) | — | |
| SCHEMBL29892782 | 0.62 | LMNA (0.53) | ALDH1A1BRD9LMNASMN1; SMN2MAPK1 | |
| SCHEMBL27606197 | 0.61 | CYP2C9 (0.37) | MAPTKDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104203919-A | eterocyclic carboxamides useful as inhibitors of phosphodiesterase type 10A | ABBVIE DEUTSCHLAND | 2014-12-10 | — | — | CN | disclosed |