Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 11/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29531294 | 1.00 | IRAK4 (0.46) | IRAK4RORCSLC6A9DHODHSLC6A5 | |
| SCHEMBL29440590 | 1.00 | IRAK4 (0.46) | IRAK4RORCSLC6A9DHODHSLC6A5 | |
| SCHEMBL30617252 | 0.90 | IRAK4 (0.45) | IRAK4RORCSLC6A9PARP1JAK2 | |
| SCHEMBL28816619 | 0.87 | RORC (0.46) | RORCSLC6A9DHODHSLC6A5KCNH2 | |
| SCHEMBL28816647 | 0.84 | IRAK4 (0.65) | IRAK4PARP1 | |
| SCHEMBL28816605 | 0.83 | IRAK4 (0.68) | IRAK4RORCSLC6A9DHODHSLC6A5 | |
| SCHEMBL28816607 | 0.83 | IRAK4 (0.68) | IRAK4RORCSLC6A9DHODHSLC6A5 | |
| SCHEMBL18398482 | 0.80 | IRAK4 (0.45) | IRAK4PARP1 | |
| SCHEMBL29639497 | 0.77 | IRAK4 (0.44) | IRAK4DHODHPARP1 | |
| SCHEMBL23753927 | 0.76 | EPHX2 (0.44) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114630822-A | Biaryl dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-06-14 | — | — | CN | disclosed |