SCHEMBL28818191

SCHEMBL28818191

CC(c1ccccc1)(c1ccccc1)C(Br)Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 3/20 0.41
TAAR1 Q96RJ0 1/20 0.41
ALOX15 P16050 1/20 0.41
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
CYP3A4 P08684 1/20 0.39
KCNN4 O15554 4/20 0.39
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38
TSHR P16473 2/20 0.38
CYP2C19 P33261 1/20 0.37
HIF1A Q16665 1/20 0.37
CYP2B6 P20813 1/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3660630 0.76 TAAR1 (0.48) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL10999606 0.75 MAPK1 (0.37) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL651122 0.75 ALDH1A1 (0.43) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL1955810 0.74 TAAR1 (0.46) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL17894157 0.74 ALDH1A1 (0.46) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL413091 0.74 ALDH1A1 (0.46) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL29716732 0.74 MAPK1 (0.44) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL8319549 0.74 ALDH1A1 (0.46) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL96177 0.74 MAPK1 (0.55) MAPK1ALDH1A1TAAR1ALOX15ESR1
SCHEMBL642315 0.74 TAAR1 (0.57) MAPK1ALDH1A1TAAR1ALOX15ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010701-B Preparation method of nitrogen-containing heterocyclic derivative 浙江百可半导体材料有限公司 2023-10-13 CN disclosed
CN-114933586-B Nitrogen-containing heterocyclic derivative and application thereof 浙江百可半导体材料有限公司 2023-10-10 CN disclosed
CN-114933586-A Nitrogen-containing heterocyclic derivative and application thereof 浙江百可半导体材料有限公司 2022-08-23 CN disclosed