Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.69 |
| ▸ | KLK1 | P06870 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553405 | 0.85 | KLKB1 (0.64) | KLKB1KLK1KDM4EALDH1A1LMNA | |
| SCHEMBL1912400 | 0.83 | HSD17B10 (0.77) | KLKB1KLK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4785951 | 0.83 | HSD17B10 (0.59) | KLKB1KLK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL15875754 | 0.82 | KLKB1 (1.00) | KLKB1KLK1KDM4E | |
| SCHEMBL4188538 | 0.81 | HSD17B10 (0.61) | KLKB1KLK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3548974 | 0.80 | KLKB1 (0.63) | KLKB1KLK1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL948453 | 0.79 | HSD17B10 (0.61) | KLKB1KDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL19299982 | 0.79 | HSD17B10 (0.65) | KLKB1KLK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4019065 | 0.79 | HSD17B10 (0.57) | KLKB1KLK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL369349 | 0.79 | L3MBTL1 (0.58) | KLKB1HSD17B10L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103080104-B | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein | NOVARTIS AG | 2015-04-08 | — | — | CN | disclosed |