Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 3/20 | 0.57 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402758 | 0.95 | KCNB1 (0.63) | KCNB1KCNB2AURKARPS6KB1NAMPT | |
| SCHEMBL28402273 | 0.90 | KCNB1 (0.60) | KCNB1KCNB2AURKARPS6KB1NAMPT | |
| SCHEMBL28413196 | 0.89 | KCNB1 (0.66) | KCNB1KCNB2AURKARPS6KB1NAMPT | |
| SCHEMBL29793887 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2KDM4EALDH1A1LMNA | |
| SCHEMBL28257362 | 0.80 | KCNB1 (0.66) | KCNB1KCNB2KDM4EALDH1A1LMNA | |
| SCHEMBL28255806 | 0.76 | KCNB1 (0.53) | KCNB1KCNB2KDM4EALDH1A1KCNK3 | |
| SCHEMBL29793705 | 0.74 | KCNB1 (1.00) | KCNB1KCNB2KDM4EALDH1A1LMNA | |
| SCHEMBL28255850 | 0.74 | KCNB1 (0.55) | KCNB1KCNB2KDM4EALDH1A1KCNK3 | |
| SCHEMBL28256075 | 0.73 | KCNB1 (0.51) | KCNB1KCNB2KDM4EALDH1A1KCNK3 | |
| SCHEMBL28406253 | 0.72 | KCNB1 (0.56) | KCNB1KCNB2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |