Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 3/20 | 0.66 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28402758 | 0.94 | KCNB1 (0.63) | KCNB1KCNB2EPHX2POLBKCNK3 | |
| SCHEMBL28402273 | 0.90 | KCNB1 (0.60) | KCNB1KCNB2EPHX2KDM4EALDH1A1 | |
| SCHEMBL28818685 | 0.89 | KCNB1 (0.57) | KCNB1KCNB2EPHX2POLBKCNK3 | |
| SCHEMBL28255850 | 0.81 | KCNB1 (0.55) | KCNB1KCNB2POLBKCNK3KDM4E | |
| SCHEMBL29793705 | 0.80 | KCNB1 (1.00) | KCNB1KCNB2POLBKDM4EALDH1A1 | |
| SCHEMBL28255806 | 0.78 | KCNB1 (0.53) | KCNB1KCNB2POLBKCNK3KDM4E | |
| SCHEMBL16583815 | 0.76 | KCNB1 (0.69) | KCNB1KCNB2POLBKCNK3LMNA | |
| SCHEMBL28256075 | 0.75 | KCNB1 (0.51) | KCNB1KCNB2POLBKCNK3KDM4E | |
| SCHEMBL27439889 | 0.72 | ALDH1A1 (0.66) | EPHX2POLBKDM4EALDH1A1HPGD | |
| SCHEMBL28402250 | 0.72 | KCNB1 (0.83) | KCNB1KCNB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |