Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GNPAT | O15228 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28645426 | 1.00 | ECE1 (0.58) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL20263576 | 0.98 | ECE1 (0.56) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL20677159 | 0.98 | ECE1 (0.56) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL19384766 | 0.98 | ECE1 (0.56) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL18343746 | 0.98 | ECE1 (0.56) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL468796 | 0.85 | KDM4E (0.57) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL468797 | 0.85 | KDM4E (0.57) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL1204312 | 0.85 | KDM4E (0.57) | ECE1ALDH1A1GNPATKDM4EMAPT | |
| SCHEMBL31026345 | 0.85 | ECE1 (0.56) | ECE1ALDH1A1ITGB2ICAM1ITGAL | |
| SCHEMBL20789058 | 0.85 | ECE1 (0.56) | ECE1ALDH1A1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116059390-A | Prodrugs of cytotoxic actives with enzymatically cleavable groups | 拜耳制药股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-114917361-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2022-08-19 | — | — | CN | disclosed |