Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28838677 | 0.92 | HPGD (0.36) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL27688832 | 0.92 | USP2 (0.42) | USP2SMN1; SMN2HDAC2DDB1CRBN | |
| SCHEMBL22041915 | 0.89 | USP2 (0.37) | USP2SMN1; SMN2RORCDDB1CRBN | |
| SCHEMBL29053800 | 0.88 | CYP11B2 (0.36) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL29211282 | 0.85 | USP2 (0.40) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL22702488 | 0.83 | USP2 (0.45) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL14377883 | 0.81 | HPGD (0.36) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL29168763 | 0.81 | HDAC2 (0.36) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL25209207 | 0.80 | USP2 (0.42) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 | |
| SCHEMBL2673515 | 0.80 | USP2 (0.42) | CYP11B2USP2SMN1; SMN2SCD5HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117693509-A | Macrocyclic compounds for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117616031-A | RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115894606-A | RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114786777-A | RAS inhibitors | 锐新医药公司 | 2022-07-22 | — | — | CN | disclosed |