Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28822005 | 0.92 | CYP11B2 (0.37) | USP2SMN1; SMN2CYP11B2HDAC2SCD5 | |
| SCHEMBL14377883 | 0.89 | HPGD (0.36) | HPGDMKNK1USP2SMN1; SMN2MEN1 | |
| SCHEMBL22041915 | 0.87 | USP2 (0.37) | HPGDUSP2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL30453762 | 0.86 | HPGD (0.39) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30453434 | 0.86 | HPGD (0.39) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2891521 | 0.86 | HPGD (0.39) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16095519 | 0.85 | HPGD (0.38) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27688832 | 0.84 | USP2 (0.42) | HPGDUSP2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3157569 | 0.81 | HPGD (0.41) | HPGDUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29053800 | 0.81 | CYP11B2 (0.36) | USP2SMN1; SMN2CYP11B2HDAC2SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209438-A | Treatment of malignant diseases with SHP2 mutations using SOS1 inhibitors | 锐新医药公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115873020-A | RAS inhibitors | 锐新医药公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-114901366-A | RAS inhibitors | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |