Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL10934156 | 0.94 | — | — | |
| Glycine SCHEMBL28136144 | 0.84 | GLRA1 (0.50) | GLRA1SLC6A9OR51E2GABRR1CYP1A2 | |
| Glycine SCHEMBL22206093 | 0.82 | — | — | |
| Glycine SCHEMBL27969394 | 0.78 | — | — | |
| Glycine SCHEMBL28065808 | 0.78 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1CYP1A2 | |
| Glycine SCHEMBL1001780 | 0.78 | — | — | |
| Glycine SCHEMBL28841659 | 0.78 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1CYP1A2 | |
| Glycine SCHEMBL16423760 | 0.78 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1CYP1A2 | |
| Malonic Acid SCHEMBL8976510 | 0.77 | LDHA (0.56) | GLRA1SLC6A9OR51E2CYP1A2LMNA | |
| Glycine SCHEMBL13739339 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105131351-A | Composite rubber material specially used for tyre inner tubes | HEFEI ZAIDE MACROMOLECULE MATERIAL CO LTD | 2015-12-09 | — | — | CN | disclosed |