Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | STK16 | O75716 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034955 | 0.81 | SLC22A12 (0.50) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL14690611 | 0.79 | SLC22A12 (0.51) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL29896761 | 0.79 | SLC22A12 (0.51) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL16247955 | 0.76 | SLC22A12 (0.49) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL360254 | 0.76 | SLC22A12 (0.51) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL436939 | 0.76 | NR4A2 (0.61) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL359558 | 0.76 | NT5E (0.50) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL741042 | 0.76 | SLC22A12 (0.53) | SLC22A12CHEK1PIM1AKT1FLT3 | |
| SCHEMBL5539375 | 0.76 | HTR1A (0.54) | SLC22A12FLT3PIM3CDK8HTT | |
| SCHEMBL729828 | 0.76 | SLC22A12 (0.49) | SLC22A12CHEK1PIM1AKT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143228-B | [1,2,4] triazol [4,3 a] pyridine derivatives, its preparation method or its in application pharmaceutically | 江苏豪森药业集团有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-105143228-A | [1,2,4]triazol[4,3-a]pyridine derivate, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-12-09 | — | — | CN | disclosed |