SCHEMBL28823451

SCHEMBL28823451

Cc1ccc(C(C)CBr)cc1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.48
STAT3 P40763 1/20 0.44
GRIA4 P48058 1/20 0.42
CHRNA7 P36544 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
ALDH1A1 P00352 1/20 0.38
GSK3B P49841 1/20 0.37
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
ALOX5 P09917 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
MAOA P21397 2/20 0.34
MAOB P27338 1/20 0.34
CA7 P43166 1/20 0.34
IDO1 P14902 1/20 0.33
GBA1 P04062 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28129332 1.00 ACHE (0.48) ACHESTAT3GRIA4CHRNA7TDP1
SCHEMBL28142952 1.00 ACHE (0.48) ACHESTAT3GRIA4CHRNA7TDP1
SCHEMBL11024335 0.89 ESR1 (0.41) ACHEESR1ESR2TAAR1
SCHEMBL14658424 0.81 ACHE (0.46) ACHESTAT3GRIA4CHRNA7TDP1
SCHEMBL10456468 0.80 PYCR1 (0.41) ALDH1A1ESR1ESR2ALOX5MAOA
SCHEMBL5871371 0.78 AOC3 (0.38) ACHEMAOAMAOBIDO1
SCHEMBL19361125 0.78 CYP1A2 (0.36) ACHEGSK3BESR1ESR2TAAR1
SCHEMBL583097 0.77 TAAR1 (0.58) ALDH1A1TAAR1
SCHEMBL8159872 0.77 TAAR1 (0.58) ALDH1A1TAAR1
SCHEMBL6327571 0.77 ACHE (0.50) ACHESTAT3GRIA4CHRNA7TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105198692-A Method for asymmetrically catalyzing and synthesizing (S)-curcumene UNIV CHINA AGRICULTURAL 2015-12-30 CN disclosed