Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28189261 | 0.86 | NPC1 (0.57) | SYKBTKITKEGFRNPC1 | |
| SCHEMBL27971524 | 0.84 | SYK (0.49) | SYKBTKITKEGFR | |
| SCHEMBL18780747 | 0.81 | SYK (0.48) | SYKITKEGFRNPC1RAB9A | |
| SCHEMBL30350991 | 0.78 | TRPV1 (0.55) | — | |
| SCHEMBL28850302 | 0.78 | SYK (0.50) | SYKITKEGFRNPC1RAB9A | |
| SCHEMBL17266536 | 0.77 | JAK3 (0.58) | SYKBTKAURKAKDR | |
| SCHEMBL28039312 | 0.76 | SYK (0.48) | SYKITKNPC1RAB9AAURKA | |
| SCHEMBL28039617 | 0.75 | SYK (0.48) | SYKITKNPC1RAB9AAURKA | |
| SCHEMBL30737936 | 0.75 | AURKA (0.56) | NPC1RAB9AAURKAAURKB | |
| SCHEMBL13921824 | 0.73 | SYK (0.60) | SYKITKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968664-A | BICYCLIC COMPOUND FUNCTIONING AS TYROSINE KINASE INHIBITOR | KBP BIOSCIENCES CO LTD | 2015-10-07 | — | — | CN | disclosed |