Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28850302 | 0.83 | SYK (0.50) | SYKROCK1BRD4CYP17A1ITK | |
| SCHEMBL28039312 | 0.81 | SYK (0.48) | SYKROCK1BRD4CYP17A1ITK | |
| SCHEMBL28189261 | 0.81 | NPC1 (0.57) | SYKROCK1ITKAURKAAURKB | |
| SCHEMBL13498138 | 0.77 | BTK (0.50) | SYKBRD4KAT6ANPC1RAB9A | |
| SCHEMBL29029431 | 0.75 | HDAC3 (0.56) | SYKBRD4CYP17A1KAT6ANAMPT | |
| SCHEMBL17266536 | 0.75 | JAK3 (0.58) | SYKROCK1AURKA | |
| SCHEMBL28823474 | 0.75 | SYK (0.52) | SYKITKAURKAAURKBNPC1 | |
| SCHEMBL18780747 | 0.74 | SYK (0.48) | SYKITKAURKAAURKBNPC1 | |
| SCHEMBL690643 | 0.74 | CDK1 (0.49) | SYKBRD4CYP17A1AURKAAURKB | |
| SCHEMBL14959269 | 0.74 | THRB (0.53) | SYKBRD4CYP17A1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968664-A | BICYCLIC COMPOUND FUNCTIONING AS TYROSINE KINASE INHIBITOR | KBP BIOSCIENCES CO LTD | 2015-10-07 | — | — | CN | disclosed |