Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24521475 | 0.82 | SMN1; SMN2 (0.43) | MEN1KMT2AALDH1A1EPHX2SMN1; SMN2 | |
| SCHEMBL3762272 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1LMNACHRNB2CHRNA3 | |
| SCHEMBL3757533 | 0.79 | HPGD (0.36) | ALDH1A1LMNAMAPK1HPGDKDM4E | |
| SCHEMBL16042352 | 0.77 | ALDH1A1 (0.39) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL12182476 | 0.76 | MEN1 (0.58) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL478307 | 0.75 | ALDH1A1 (0.71) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL22474755 | 0.75 | ALDH1A1 (0.71) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL15014489 | 0.75 | ALDH1A1 (0.71) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL10305071 | 0.75 | MEN1 (0.47) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL13612864 | 0.75 | MEN1 (0.47) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324380-A | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-02-10 | — | — | CN | disclosed |
| CN-105246890-A | Pyrrolo[2, 3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-01-13 | — | — | CN | disclosed |