Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909103 | 0.86 | PKM (0.41) | SMN1; SMN2ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL21281054 | 0.86 | PKM (0.41) | SMN1; SMN2ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL22891320 | 0.86 | PKM (0.41) | SMN1; SMN2ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL24521448 | 0.86 | MEN1 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28824429 | 0.82 | MEN1 (0.46) | SMN1; SMN2ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL24244801 | 0.80 | MEN1 (0.48) | SMN1; SMN2ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL12313355 | 0.78 | MEN1 (0.54) | ALDH1A1EPHX2MEN1KMT2AKDM4E | |
| SCHEMBL18909248 | 0.77 | KDM2B (0.42) | ALDH1A1EPHX2PKMKDM4EL3MBTL1 | |
| SCHEMBL12452076 | 0.77 | MEN1 (0.56) | ALDH1A1EPHX2MEN1KMT2AKDM4E | |
| SCHEMBL12801561 | 0.72 | L3MBTL3 (0.51) | ALDH1A1EPHX2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |