Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049358 | 0.84 | DYRK1A (0.51) | CLK4DYRK1AKCNA5AURKAPDE4B | |
| SCHEMBL10094648 | 0.83 | DYRK1A (0.62) | CLK4DYRK1AKCNA5AURKATOP1 | |
| SCHEMBL15674640 | 0.82 | PDE4B (0.53) | KCNA5PDE10APDE4BPDE7APDE3A | |
| SCHEMBL7230871 | 0.82 | MAP4K4 (0.50) | CDK5CDK5R1CYP3A4ALDH1A1NPC1 | |
| SCHEMBL15674440 | 0.82 | PDGFRB (0.51) | CLK4PDGFRBPDGFRAPDE4BGSK3B | |
| SCHEMBL27866855 | 0.82 | DYRK1A (0.60) | CLK4DYRK1AKCNA5AURKATOP1 | |
| SCHEMBL27265882 | 0.82 | DYRK1A (0.60) | CLK4DYRK1AKCNA5AURKATOP1 | |
| SCHEMBL987247 | 0.80 | SYK (0.51) | PDGFRBPDGFRAPDE3ALMNAKDM4E | |
| SCHEMBL16047508 | 0.80 | KCNA5 (0.62) | CLK4DYRK1AKCNA5AURKATOP1 | |
| SCHEMBL10094501 | 0.80 | DYRK1A (0.57) | CLK4DYRK1AKCNA5AURKATOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105051044-A | Compounds and their use for modulating hemoglobin | GLOBAL BLOOD THERAPEUTICS INC | 2015-11-11 | — | — | CN | disclosed |