Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | GAPDH | P04406 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28824499 | 0.84 | CLK4 (0.62) | DYRK1ACLK4ALDH1A1KDM4EHPGD | |
| SCHEMBL27504690 | 0.82 | MAP4K4 (0.44) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL6717844 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHTTL3MBTL1 | |
| SCHEMBL4052629 | 0.79 | GAPDH (0.46) | MEN1KMT2AALDH1A1HPGDGAPDH | |
| SCHEMBL27489306 | 0.78 | PDE4D (0.55) | ALDH1A1KDM4EPDE4APDE4BPDE4C | |
| SCHEMBL22160863 | 0.78 | DHODH (0.59) | DYRK1ACLK4MEN1KMT2AALDH1A1 | |
| SCHEMBL30832877 | 0.78 | DHODH (0.59) | DYRK1ACLK4MEN1KMT2AALDH1A1 | |
| SCHEMBL24313994 | 0.77 | HTT (0.56) | ALDH1A1KDM4EGAPDHHTTPKM | |
| SCHEMBL6174210 | 0.77 | JAK2 (0.56) | DYRK1ACLK4MEN1KMT2AKDM4E | |
| SCHEMBL26009136 | 0.76 | LMNA (0.59) | ALDH1A1GAPDHHTTBACE1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |