Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.96 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.96 |
| ▸ | MEN1 | O00255 | 3/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.96 |
| ▸ | CASP1 | P29466 | 2/20 | 0.96 |
| ▸ | HBB | P68871 | 2/20 | 0.96 |
| ▸ | NPC1 | O15118 | 2/20 | 0.96 |
| ▸ | RAB9A | P51151 | 2/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.96 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.60 |
| ▸ | CHKA | P35790 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27884858 | 1.00 | MAPT (0.96) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| Bromide SCHEMBL27779245 | 1.00 | MAPT (0.96) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL305456 | 0.98 | MAPT (1.00) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL532373 | 0.98 | MAPT (1.00) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| Hydrochloric Acid SCHEMBL9803944 | 0.96 | MAPT (0.96) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| Hydrochloric Acid SCHEMBL9803942 | 0.96 | MAPT (0.96) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL5887491 | 0.85 | MAPT (0.77) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL1714446 | 0.84 | RELA (0.81) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL3025040 | 0.84 | RELA (0.81) | MAPTSMN1; SMN2MEN1KMT2ACASP1 | |
| SCHEMBL13467434 | 0.84 | RELA (0.81) | MAPTSMN1; SMN2MEN1KMT2ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153018-A | Hemicyanine derivative pH fluorescence ratio sensor | UNIV BEIJING TECH & BUSINESS | 2015-12-16 | — | — | CN | disclosed |