SCHEMBL28824786

SCHEMBL28824786

O=C(NC(Cc1ccc2ccccc2n1)c1ccccc1)OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 8/20 0.47
CASP7 P55210 6/20 0.47
CYSLTR1 Q9Y271 3/20 0.47
CYSLTR2 Q9NS75 2/20 0.47
CTRB1 P17538 2/20 0.46
CASP1 P29466 2/20 0.46
CASP9 P55211 2/20 0.46
TACR1 P25103 1/20 0.46
CTSL P07711 1/20 0.44
CTSS P25774 1/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP1A2 P05177 1/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29858069 1.00 CASP3 (0.47) CASP3CASP7CYSLTR1CYSLTR2CTRB1
SCHEMBL28824795 0.87 KMT2A (0.49) CYSLTR1CYSLTR2ALDH1A1CYP1A2
SCHEMBL29858159 0.87 KMT2A (0.49) CYSLTR1CYSLTR2ALDH1A1CYP1A2
SCHEMBL21467795 0.87 KMT2A (0.49) CYSLTR1CYSLTR2ALDH1A1CYP1A2
SCHEMBL21467676 0.85 CYP1A2 (0.47) CYSLTR1CYSLTR2CYP1A2
SCHEMBL29858135 0.85 CYP1A2 (0.47) CYSLTR1CYSLTR2CYP1A2
SCHEMBL28824775 0.85 CYP1A2 (0.47) CYSLTR1CYSLTR2CYP1A2
SCHEMBL28824792 0.85 CYP1A2 (0.45) CASP3CASP7CYSLTR1CYSLTR2ALDH1A1
SCHEMBL29858123 0.85 CYP1A2 (0.45) CASP3CASP7CYSLTR1CYSLTR2ALDH1A1
SCHEMBL21459042 0.82 CYP1A2 (0.48) CYSLTR1CYSLTR2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109563045-B Pd (II) -catalysed enantioselective beta-methylene C (sp) 3 ) -H bond activation 斯克里普斯研究学院 2022-08-23 CN disclosed