Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MPI | P34949 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14754042 | 0.85 | ALDH1A1 (0.38) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14736017 | 0.84 | ALDH1A1 (0.37) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14742195 | 0.83 | ALDH1A1 (0.36) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14736130 | 0.83 | ALDH1A1 (0.36) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL14736216 | 0.82 | L3MBTL1 (0.42) | KDM4ELMNACYP3A4ALDH1A1MEN1 | |
| SCHEMBL14742430 | 0.82 | ALDH1A1 (0.36) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28048048 | 0.75 | KDM4E (0.43) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14736088 | 0.68 | PIK3CD (0.33) | — | |
| SCHEMBL14736760 | 0.67 | PIK3CD (0.36) | — | |
| SCHEMBL14742221 | 0.67 | EGLN2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986867-B | Heterocycle amine as PI3K inhibitor | 因塞特控股公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-109010343-A | The purposes of Pyrazolopyrimidine derivative treatment PI3K δ associated disease | 因赛特公司 | 2018-12-18 | — | — | CN | disclosed |
| CN-104024253-B | Heterocyclic amines as PI3K inhibitors | INCYTE HOLDINGS CORP. (US) | 2016-11-30 | — | — | CN | disclosed |
| CN-105120871-A | Use of pyrazolopyrimidine derivatives for the treatment of PI 3K-related disorders | INCYTE CORP | 2015-12-02 | — | — | CN | disclosed |