Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825547 | 0.83 | GAA (0.44) | GAAMAPTKLKB1GRIN2BGRIN1 | |
| SCHEMBL28825448 | 0.81 | GAA (0.47) | GAAMAPTCYP11B1CYP11B2HTT | |
| SCHEMBL28825473 | 0.80 | GAA (0.46) | GAAMAPTHTTKLKB1GRIN2B | |
| SCHEMBL28825562 | 0.80 | GAA (0.52) | GAAMAPTHTTKLKB1GRIN2B | |
| SCHEMBL28825510 | 0.79 | GRIN2B (0.52) | GAAMAPTKLKB1GRIN2BGRIN1 | |
| SCHEMBL28825588 | 0.78 | GAA (0.50) | GAAMAPTHTTKLKB1GRIN2B | |
| SCHEMBL28931688 | 0.77 | KCNH2 (0.45) | GAAMAPTGRIN2BGRIN1 | |
| SCHEMBL28949597 | 0.76 | GAA (0.42) | GAAMAPTKLKB1GRIN2BGRIN1 | |
| SCHEMBL28825653 | 0.75 | GAA (0.44) | GAAMAPTCYP11B1CYP11B2HTT | |
| SCHEMBL28825487 | 0.75 | GRIN2B (0.51) | GAAMAPTKLKB1GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |