Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 18/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 15/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825482 | 0.89 | GRIN2B (0.51) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28825489 | 0.88 | GRIN2B (0.48) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL28949575 | 0.88 | GRIN2B (0.47) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL28949561 | 0.86 | GRIN2B (0.54) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28694730 | 0.86 | GRIN2B (0.52) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28825508 | 0.83 | GRIN2B (0.47) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28825542 | 0.82 | GRIN2B (0.51) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28825552 | 0.82 | CYP11B2 (0.58) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28949601 | 0.81 | GRIN2B (0.49) | GRIN2BGRIN1KDM1AHDAC1HDAC2 | |
| SCHEMBL28949594 | 0.81 | MAPT (0.44) | GRIN2BGRIN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |