Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825461 | 0.89 | CYP11B1 (0.51) | GRIN1GRIN2BKDM1AHDAC1CYP11B1 | |
| SCHEMBL28825694 | 0.88 | GRIN1 (0.42) | GRIN1GRIN2BKDM1AHDAC1CYP11B1 | |
| SCHEMBL28825564 | 0.85 | GRIN1 (0.44) | GRIN1GRIN2BKDM1AHDAC1CYP11B1 | |
| SCHEMBL28964551 | 0.81 | KDM4E (0.55) | GRIN1GRIN2BKDM1AHDAC1KCNH2 | |
| SCHEMBL28825507 | 0.81 | SMN1; SMN2 (0.45) | GRIN1GRIN2BKDM1AHDAC1KCNH2 | |
| SCHEMBL28825484 | 0.81 | GRIN1 (0.43) | GRIN1GRIN2BKDM1AHDAC1KCNH2 | |
| SCHEMBL28825571 | 0.79 | CYP11B1 (0.45) | GRIN1GRIN2BKDM1AHDAC1CYP11B1 | |
| SCHEMBL28825444 | 0.76 | SMN1; SMN2 (0.46) | GRIN1GRIN2BKDM1AHDAC1KCNH2 | |
| SCHEMBL28825613 | 0.75 | SMN1; SMN2 (0.48) | GRIN1GRIN2BKDM1AHDAC1KCNH2 | |
| SCHEMBL28949586 | 0.72 | KDM4E (0.45) | GRIN1GRIN2BKDM1AHDAC1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |