Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825474 | 0.86 | GRIN2B (0.51) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 | |
| SCHEMBL28825477 | 0.78 | GRIN2B (0.49) | GRIN1GRIN2BSMN1; SMN2NPC1KDM4E | |
| SCHEMBL28825453 | 0.76 | GRIN2B (0.50) | GRIN1GRIN2BSMN1; SMN2NPC1MAPT | |
| SCHEMBL28825450 | 0.76 | GRIN2B (0.49) | GRIN1GRIN2BSMN1; SMN2MAPTKDM1A | |
| SCHEMBL28825506 | 0.76 | GRIN2B (0.48) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 | |
| SCHEMBL28825439 | 0.74 | GRIN2B (0.47) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 | |
| SCHEMBL28694730 | 0.74 | GRIN2B (0.52) | GRIN1GRIN2BKDM1AHDAC1HDAC2 | |
| SCHEMBL28825546 | 0.74 | GRIN2B (0.53) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 | |
| SCHEMBL28825502 | 0.73 | MAPT (0.46) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 | |
| SCHEMBL28825613 | 0.73 | SMN1; SMN2 (0.48) | GRIN1GRIN2BSMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |