Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825613 | 0.92 | SMN1; SMN2 (0.48) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28825563 | 0.78 | GRIN1 (0.53) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28825571 | 0.76 | CYP11B1 (0.45) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28825641 | 0.74 | GRIN1 (0.50) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28825474 | 0.72 | GRIN2B (0.51) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28825651 | 0.72 | GRIN1 (0.52) | GRIN2BGRIN1SMN1; SMN2MAPTCYP11B1 | |
| SCHEMBL28825461 | 0.71 | CYP11B1 (0.51) | GRIN2BGRIN1SMN1; SMN2NPC1MAPT | |
| SCHEMBL28825549 | 0.71 | GRIN2B (0.40) | GRIN2BGRIN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL28825444 | 0.71 | SMN1; SMN2 (0.46) | GRIN2BGRIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15730160 | 0.69 | MKNK1 (0.50) | GRIN2BGRIN1TOP1ALDH1A1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |