Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367304 | 0.86 | GSK3B (0.47) | MAPTRAB9AGSK3BNOTUMMAPK1 | |
| SCHEMBL7779146 | 0.84 | PTPN1 (0.58) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL30580694 | 0.84 | PTPN1 (0.58) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL5312305 | 0.83 | TAS1R3 (0.49) | GSK3BMAPK1TRPA1ALDH1A1HIF1A | |
| SCHEMBL12097542 | 0.80 | MAPT (0.54) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL6313753 | 0.80 | PLOD2 (0.56) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL20714412 | 0.80 | MAPT (0.48) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL20714414 | 0.80 | MAPT (0.49) | MAPTNPSR1XBP1HTTMEN1 | |
| SCHEMBL14419584 | 0.80 | GSK3B (0.52) | MAPTRAB9AGSK3BMAPK1TRPA1 | |
| SCHEMBL20703102 | 0.79 | MAPT (0.47) | MAPTNPSR1XBP1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103415507-B | As the 3-amino-pyridine class of GPBAR1 agonist | HOFFMAN-LA ROCHE LTD. (CH) | 2016-03-02 | — | — | CN | disclosed |