Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698799 | 0.83 | ERN1 (0.62) | ERN1TDP1GPR35MAPTL3MBTL1 | |
| SCHEMBL12481825 | 0.81 | ERN1 (0.47) | ERN1TDP1GPR35MAPTL3MBTL1 | |
| SCHEMBL16952150 | 0.81 | ERN1 (0.51) | ERN1TDP1GPR35MAPTL3MBTL1 | |
| SCHEMBL2550458 | 0.80 | MAPT (0.55) | ERN1TDP1MAPTNPC1RAB9A | |
| SCHEMBL3010961 | 0.80 | TDP1 (0.61) | ERN1TDP1GPR35TSHRALDH1A1 | |
| SCHEMBL7768221 | 0.79 | ERN1 (0.49) | ERN1TDP1GPR35MAPTL3MBTL1 | |
| SCHEMBL24492388 | 0.79 | FBP1 (0.51) | ERN1TDP1GPR35MAPTLMNA | |
| SCHEMBL28704930 | 0.79 | FBP1 (0.51) | ERN1TDP1GPR35MAPTLMNA | |
| Ammonia Solution, Strong SCHEMBL28763100 | 0.78 | TDP1 (0.58) | ERN1TDP1GPR35TSHRALDH1A1 | |
| SCHEMBL3073529 | 0.77 | ERN1 (0.47) | ERN1TDP1GPR35MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104169283-B | Fused quaternary or five-membered ring pyridophthalazinones as PARP inhibitors | BEIGENE, LTD. (KY) | 2016-05-18 | — | — | CN | disclosed |