Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ilaprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 8/20 | 0.39 |
| ▸ | ATP4B known ✓ | P51164 | 8/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 6/20 | 0.39 |
| ▸ | ATP1B1 | P05026 | 6/20 | 0.39 |
| ▸ | ATP1A3 | P13637 | 6/20 | 0.39 |
| ▸ | ATP1B2 | P14415 | 6/20 | 0.39 |
| ▸ | ATP1A2 | P50993 | 6/20 | 0.39 |
| ▸ | ATP1B3 | P54709 | 6/20 | 0.39 |
| ▸ | FXYD2 | P54710 | 6/20 | 0.39 |
| ▸ | ATP1A4 | Q13733 | 6/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ilaprazole SCHEMBL1652136 | 0.98 | ATP4A (0.40) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL29684589 | 0.97 | ATP4A (0.39) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL1179039 | 0.91 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL22734706 | 0.91 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL29364741 | 0.91 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL23988478 | 0.91 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL22734704 | 0.91 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL8470106 | 0.90 | ATP1A1 (0.36) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL14022064 | 0.85 | ATP1A1 (0.32) | ATP4AATP4BATP1A1ATP1B1ATP1A3 | |
| Ilaprazole SCHEMBL14022063 | 0.85 | ATP1A1 (0.33) | ATP4AATP4BATP1A1ATP1B1ATP1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403560-A | Ilaprazole magnesium crystal form and preparation method thereof | 丽珠医药集团股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-107857756-B | Ilaprazole magnesium crystal form and preparation method thereof | 丽珠医药集团股份有限公司 | 2022-08-30 | — | — | CN | disclosed |